CLINICAL
NEWS JACC in a FLASH
The authors found
that volumes of
moderate and
vigorous exercise
below recommendations resulted in
significantly lower
mortality risk.
calcium scores. Two recent studies
reported a U-shaped relationship
between aerobic exercise volumes
and cardiovascular morbidity and
mortality in the general population.
However, findings also show that
daily exercise regardless of activity may reduce the incidence the
incidence of cerebrovascular disease
and venous thromboembolism. Any
volume of strenuous exercise may
also reduce the risk for incident
coronary artery disease. Exerciseinduced changes in cardiac structure
and function are usually related to
the volume and intensity of athletic
activity. However, the authors explain that while the long-term implications are currently unknown, it is
unlikely these are similar to the risk
classifications seen in CVD patients.
Many endurance athletes experience cardiovascular benefits as well.
“Even though exercise and exercise
UNRESTRICTED COMMERCIAL AND
MEDICARE PART D FORMULARY
COVERAGE NATIONWIDE
FOR YOUR PATIENTS ON EFFIENT® (PRASUGREL)
NATIONAL COVERAGE FOR EFFIENT*
90 + 88
%
Commercial†
%
Medicare Part D‡
*Access defined as unrestricted lowest brand co-pay (LBC) or 2nd LBC.
The paper also explored the role
of exercise as a key component in
secondary prevention for patients
with CVD. Guidelines from the
ACC and the American Heart Association recommend 30–60 minutes of moderate intensity aerobic
exercises per day, and also advise
patients to included resistance exercise training. Patients with certain
conditions, such as myocardial infarction, recent cardiac surgery or
a percutaneous coronary intervention are eligible for cardiac rehabilitation, which includes exercise
training. While there are obvious
benefits from exercise for patients
with CVD, high volumes of exercise may be harmful. However, the
paper highlights recent studies that
have found high intensity interval
training may be beneficial.
Lastly, the paper looks at the
controversy surrounding excessive exercise. Multiple studies have
found that endurance athletes
may be at a higher risk for adverse
cardiovascular outcomes. Large
volumes of intense exercise may
lead to increased risk for atrial
fibrillation, post-exercise decreases
in left and right ventricular function, and increased coronary artery
14
Approximately 73%† of commercial and 80%‡ of
Medicare Part D patients have unrestricted access
to Effient at the LBC amount or better
Source: Managed Markets Insight & Technology (MMIT), LLC as of June 2015, and is subject to change
without notice by a health plan or state. Please contact the plan or state for the most current information
This information is not a guarantee of coverage or payment (partial or full). Actual benefits are determined
by each plan administrator in accordance with its respective policy and procedures
Formulary information in this document does not establish clinical comparability of products and should
not be seen as making any claim regarding efficacy or safety
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