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S:7 in
Corlanor® (ivabradine)
Ivabradine
N=3260
Placebo
N=3278
Bradycardia
10%
2.2%
Hypertension, blood
pressure increased
8.9%
7.8%
Atrial fibrillation
8.3%
6.6%
Phosphenes, visual
brightness
2.8%
0.5%
Monitor pregnant women with chronic heart failure in 3rd
trimester of pregnancy for preterm birth.
Data
Animal Data
In pregnant rats, oral administration of ivabradine during
the period of organogenesis (gestation day 6-15) at doses of
2.3, 4.6, 9.3, or 19 mg/kg/day resulted in fet