CLINICAL
NEWS JACC in a FLASH
services,” the authors write. The
researchers also found that costs
were much higher for patients with
concurrent cardiovascular disease,
but differences between smokers and
nonsmokers were only slightly higher
in this group. The researchers believe
that this study shows that there is “a
major opportunity to improve individual and population health, and to
do so cost effectively.”
In an accompanying editorial comment, Geoffrey D. Barnes MD, MSc,
and Elizabeth A. Jackson, MD, MPH,
write that based on these findings,
“it would seem logical to define PAD
patients as a highest-risk group for
adverse outcomes and thus increased
health care costs; therefore making it
an important population to target for
nicotine replacement coverage and/or
financial incentives for tobacco abstinence. This is especially paramount
since the increased health care costs
BRIEF SUMMARY OF PRESCRIBING INFORMATION
Methotrexate: Salicylate can inhibit renal clearance of methotrexate,
leading to bone marrow toxicity, especially in the elderly or renal impaired.
The following is a brief summary only; see full Prescribing Information
for complete product information.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs): The concurrent use
of DURLAZA with other NSAIDs increases the risk of bleeding and
may result in renal impairment. Ibuprofen can interfere with the
anti-platelet effect of low dose aspirin. Patients who use DURLAZA
and take a single dose of ibuprofen 400 mg should dose the ibuprofen
at least 2-4 hours or longer after ingestion of DURLAZA. Wait 8 hours
after ibuprofen dosing, before giving aspirin, to avoid significant
interference. Nonselective NSAIDs may interfere with the antiplatelet
effect of low-dose aspirin.
DURLAZATM (aspirin) Extended Release Capsules, for oral use
INDICATIONS AND USAGE
DURLAZA is indicated to:
1. Reduce the risk of death and myocardial infarction (MI) in patients
with chronic coronary artery disease, such as patients with a history
of MI or unstable angina pectoris or with chronic stable angina
2. Reduce the risk of death and recurrent stroke in patients who have
had an ischemic stroke or transient ischemic attack
Limitation of Use: Use immediate-release aspirin, not EU$