CardioSource WorldNews July 2015 | Page 25

HEART FAILURE
SHATTERS
MILLIONS OF LIVES
HEART FAILURE PATIENTS: “STABLE” OR SILENTLY PROGRESSING?
Heart failure is a progressive disease that is characterized by frequent hospital
admissions and high mortality rates:

HEART FAILURE
HOSPITALIZATIONS
OCCUR EVERY YEAR1

OF HEART FAILURE
PATIENTS DIE WITHIN
1 YEAR OF DIAGNOSIS3

and rehospitalization
continues to be an issue2

this increases to ~50%
within 5 years3,4

LET’S WORK TOGETHER
The neurohormonal imbalance associated with chronic heart failure is a major contributing
TO ofCHANGE
THAT
factor to the progression
the disease. Sustained
overactivation of the RAAS and SNS, with
dysfunction of the normal counterregulatory effects of the NPS and other compensatory
mediators,* lead to impairment in heart function and cardiac remodeling.5-8

LET’S WORK TOGETHER TO CHANGE THAT

Learn more at InsideHeartFailure.com: your dedicated heart failure resource.
*Additional counterregulatory mediators include adrenomedullin, prostaglandin E, bradykinin, etc.8
NPS = natriuretic peptide system; RAAS = renin-angiotensin-aldosterone system; SNS = sympathetic nervous system.
References: 1. Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics – 2015 Update: A Report From
the American Heart Association. Circulation. 2015;131:e1-294. 2. Bradley EH, Curry L, Horwitz LI, et al. Hospital strategies
associated with 30-day readmission rates for patients with heart failure. Circ Cardiovasc Qual Outcomes. 2013;6(4):444-450.
3. Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med.
2002;347(18):1397-1402. 4. Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a
community-based population. JAMA. 2004;292(3):344-350. 5. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison’s Principles
of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 6. Boerrigter G, Costello-Boerrigter L, Burnett JC Jr. Alterations in renal
function in heart failure. In: Mann DL, ed. Heart Failure: A Companion to Braunwald’s Heart Disease. 2nd ed. St Louis: Saunders; 2011.
7. McMurray J, Komajda M, Anker S, et al. Heart failure: epidemiology, pathophysiology and diagnosis. In: Camm AJ, Lüscher TF,
Serruys PW, eds. ESC Textbook of Cardiovascular Medicine. New York: Oxford University Press; 2009. 8. Mann DL, Zipes DP, Libby P,
Bonow RO, eds. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia: Saunders; 2015.

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