CardioSource WorldNews December 2014 - Page 31

HEART FAILURE SHATTERS MILLIONS OF LIVES HEART FAILURE PATIENTS: “STABLE” OR SILENTLY PROGRESSING? Heart failure is a progressive disease that is characterized by frequent hospital admissions and high mortality rates: HEART FAILURE HOSPITALIZATIONS OCCUR EVERY YEAR1 OF HEART FAILURE PATIENTS DIE WITHIN 1 YEAR OF DIAGNOSIS3 and rehospitalization continues to be an issue2 this increases to ~50% within 5 years3,4 LET’S WORK TOGETHER TO CHANGE THAT The neurohormonal imbalance associated with chronic heart failure is a major contributing factor to the progression of the disease. Sustained overactivation of the RAAS and SNS, with dysfunction of the normal counterregulatory effects of the NPS and other compensatory mediators,* lead to impairment in heart function and cardiac remodeling.5-7 LET’S WORK TOGETHER TO CHANGE THAT *Additional counterregulatory mediators include adrenomedullin, prostaglandin E, bradykinin, etc.8 NPS=natriuretic peptide system; RAAS=renin-angiotensin-aldosterone system; SNS=sympathetic nervous system. References: 1. Go AS, Mozaffarian D, Roger VR, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28-e292. 2. Bradley EH, Curry L, Horwitz LI, et al. Hospital strategies associated with 30-day readmission rates for patients with heart failure. Circ Cardiovasc Qual Outcomes. 2013;6(4):444-450. 3. Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397-1402. 4. Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population. JAMA. 2004;292(3):344-350. 5. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison’s Principles of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008. 6. Boerrigter G, Costello-Boerrigter L, Burnett JC Jr. Alterations in renal function in heart failure. In: Mann DL, ed. Heart Failure: A Companion to Braunwald’s Heart Disease. 2nd ed. St Louis: Saunders; 2011. 7. McMurray J, Komajda M, Anker S, et al. Heart failure: epidemiology, pathophysiology and diagnosis. In: Camm AJ, Lüscher TF, Serruys PW, eds. ESC Textbook of Cardiovascular Medicine. New York: Oxford University Press; 2009. 8. Mann DL, Zipes DP, Libby P, Bonow RO, eds. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia: Saunders; 2015. Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936-1080 © 2014 Novartis 11/14 LZ6-1310825