CardioSource WorldNews December 2014 | Page 31

HEART FAILURE
SHATTERS
MILLIONS OF LIVES
HEART FAILURE PATIENTS: “STABLE” OR SILENTLY PROGRESSING?
Heart failure is a progressive disease that is characterized by frequent hospital
admissions and high mortality rates:

HEART FAILURE
HOSPITALIZATIONS
OCCUR EVERY YEAR1

OF HEART FAILURE
PATIENTS DIE WITHIN
1 YEAR OF DIAGNOSIS3

and rehospitalization
continues to be an issue2

this increases to ~50%
within 5 years3,4

LET’S WORK TOGETHER
TO CHANGE THAT

The neurohormonal imbalance associated with chronic heart failure is a major contributing
factor to the progression of the disease. Sustained overactivation of the RAAS and SNS, with
dysfunction of the normal counterregulatory effects of the NPS and other compensatory
mediators,* lead to impairment in heart function and cardiac remodeling.5-7

LET’S WORK TOGETHER TO CHANGE THAT

*Additional counterregulatory mediators include adrenomedullin, prostaglandin E, bradykinin, etc.8
NPS=natriuretic peptide system; RAAS=renin-angiotensin-aldosterone system; SNS=sympathetic nervous system.
References: 1. Go AS, Mozaffarian D, Roger VR, et al. Heart disease and stroke statistics—2014 update: a report from the American
Heart Association. Circulation. 2014;129(3):e28-e292. 2. Bradley EH, Curry L, Horwitz LI, et al. Hospital strategies associated with
30-day readmission rates for patients with heart failure. Circ Cardiovasc Qual Outcomes. 2013;6(4):444-450. 3. Levy D, Kenchaiah S,
Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18):1397-1402.
4. Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population. JAMA.
2004;292(3):344-350. 5. Fauci AS, Braunwald E, Kasper DL, et al, eds. Harrison’s Principles of Internal Medicine. 17th ed. New York:
McGraw-Hill; 2008. 6. Boerrigter G, Costello-Boerrigter L, Burnett JC Jr. Alterations in renal function in heart failure. In: Mann DL,
ed. Heart Failure: A Companion to Braunwald’s Heart Disease. 2nd ed. St Louis: Saunders; 2011. 7. McMurray J, Komajda M, Anker
S, et al. Heart failure: epidemiology, pathophysiology and diagnosis. In: Camm AJ, Lüscher TF, Serruys PW, eds. ESC Textbook of
Cardiovascular Medicine. New York: Oxford University Press; 2009. 8. Mann DL, Zipes DP, Libby P, Bonow RO, eds. Braunwald’s Heart
Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia: Saunders; 2015.

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