including KRAS (n=2), HIST1H1E (n=2) and NRAS, DIS3, EGR1,
LTB, PRKD2 (all n=1).
“We did not find any chromosome translocations involving MYC (8q24.21) or the light chain loci IGK (2p12) and IGL
(22q11.2),” the authors reported. There were also no mutations in
the TP53, ATM, ATR, and ZNFH4 genes that were identified “as
unfavorable factors to MM patients’ survival.”
“We described the main genetic events that are already present
in this premalignant state,” the authors explained, proving that complex genetic instability is formed before clinical manifestation – first
at the gene level, then at the chromosome level.
The findings suggested that the transformation from MGUS
to myeloma is not due to a single genetic abnormality; rather, the
high degree of genetic abnormality in MGUS raises the possibility
that surrounding cells in the bone marrow produce factors that
preclude MGUS cells from prog ɕ