CLINICAL NEWS
Trial Roundup
ASH Clinical News’ Associate Editors select
clinical trials to keep an eye on.
BLEEDING DISORDERS
Alice Ma, MD
University of North Carolina School of Medicine
This month’s benign hematology section focuses on the prevention and management of venous thromboembolism (VTE).
The Designer D-dimer Deep-Vein
Thrombosis Diagnosis (4D) Study
(NCT02038530)
Study Design: Prospective, observational cohort study
Study Start Date: February 2014
Estimated Study Completion Date: December 2016
Study Status: Currently recruiting participants
Estimated Enrollment: 1,500
Sponsor: McMaster University
This study will assess a new diagnostic management
strategy for suspected deep-vein thrombosis (DVT) in outpatients designed to reduce the use of ultrasound testing
on the day of presentation, and reduce repeat ultrasound
testing a week after an initial normal test. Less ultrasound
testing will be performed for two reasons: More patients
will have DVT excluded by combinations of clinical pretest
probability and D-dimer results on the day of presentation and, in those who still need an ultrasound, a repeat
ultrasound one week after a normal result will only be
performed if the D-dimer result is markedly abnormal at
initial presentat