ASH Clinical News August 2015_updated | Page 55

A recombinant FVIII to prevent and control bleeding in people with hemophilia A1 Now available Novoeight® delivers the reliability he needs 0 INHIBITORS CONFIRMED1 One of the largest clinical trials with no inhibitors confirmed in 213 PTPsa,b Because he’s always looking ahead, he needs a treatment he can rely on. Introduce him to Novoeight®, an evolution in treatment that had zero inhibitors confirmed in PTPs.1,a,b Malcolm, 18 years old, lives with hemophilia A. Visit NovoeightPro.com to learn about additional features and see how Novoeight® can fit into his world. PTPs=previously treated patients. a Patients with previous inhibitors were excluded from the trial. Individuals with hemophilia A may develop inhibitors to FVIII. Monitor patients taking Novoeight ® for inhibitor formation.1 b guardian™1: a multicenter, multinational, open-label, single-arm efficacy and safety trial in 150 patients (aged 12 to 65 years) with severe hemophilia A on a prophylactic treatment regimen who were exposed to turoctocog alfa for a mean of 85 exposure days (ranging from 11 to 172 exposure days), which corresponds to approximately 6 months in the trial. 2 guardian™3: a multicenter, multinational, noncontrolled, open-label safety, efficacy, and pharmacokinetic trial in 63 previously treated pediatric patients (aged 0 to 11 years) with hemophilia A in which patients were exposed to turoctocog alfa for a mean of 60 exposure days (ranging from 20 to 104