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UP FRONT Guest Column Perish to Publish: Repeated Episodes of Peer Rejection During the Publication Process By David B. Sykes, MD, PhD; Michael T. Sykes PhD; and Darren N. Nichols, MD n adults – sensitive adults, in particular – who con- sider themselves academics, repeated episodes of peer rejection can have serious emotional repercussions. We (David B. Sykes, MD, PhD, and Darren N. Nichols, MD) experienced multiple repeated episodes of peer rejection, or MREPR, in our attempt to publish a 1,200-word essay in the medical education literature. 1 This journey from first submission to final ac- ceptance provided new insights into the process of publication and the emotional consequences of recurrent rejection. Author and biochemist Isaac Asimov wrote that “Rejection slips, however tactfully phrased, are lacerations of the soul, if not quite inventions of the devil.” The phrase “inventions of the devil” sounds rather dramatic, though certain editors come across as lacking key components of a func- tional soul. The FIGURE outlines our 11 submissions to nine journals over a period of 915 days. Ten of these submissions resulted in rejec- tion, with a variety of proffered explanations. Many journals were kind, saying that they felt quite badly that they could not accept our work (“gentle rejection”). Others suggested that our work was perhaps best placed elsewhere (“deflective rejection” or “It’s not you, it’s me”). Still other journals coldly cited the ratio of submis- sions to accepted papers as a rationale (“statistical rejection”). Throughout the process, our manuscript underwent major reworkings. During this period, many colleagues read and made changes to the paper; whole paragraphs were both created and omitted. On day 365, our seventh submission went back to our original target journal (“Journal #1”). The column editor rejected our resubmission within 24 hours ASHClinicalNews.org with the following comment: “This manuscript is nearly identi- cal to one you submitted one year ago, which was rejected.” This comment surprised (DNN) and saddened (DBS) us. It also prompted us to seek the help of an available expert (Michael T. Sykes, PhD) to analyze the similarities among the various manuscript drafts. As one can see clearly in the FIGURE , the resubmitted manuscript showed only a 55-percent similarity to the original. We were asked to resist forwarding this graph to the journal editor, as it was felt to represent rather passive-aggressive behavior on our part. Remarkably, just when we thought that we were running out of journals to which the essay could be submitted, the manu- script slipped past the editors and went out for its first peer review on day 748. We were delighted! We never expected the peer reviewers to want so many ad- ditional changes to a manuscript that already bore little resem- blance to the original. Comments such as “title does not work” and “very confusing” left us shaken, but we remained motivated for another rewrite. Still, our reviewers were not satisfied. We managed more changes under the guidance of “try to add dialogue” and “you can do more,” bringing our paper similarity score down to an all- time low of 24 percent, at which time the manuscript was finally accepted for publication. Joy at last! Like a phoenix reborn, we flew high on our lofty success in the peer-review process. Laudatory emails full of hyperbole flew back and forth. Feeling invincible, our tall lattés were upgraded to venti- sized and gingerbread-flavored – with little caloric or fiscal regard. As though suffering from an edi- torial Stockholm syndrome, the Repeated Episodes of Peer Rejection During the Process of Publishing a Brief Editorial FIGURE. TABLE. Categories of Peer Review Rejection Gentle rejection • “I am sorry to disappoint you on this occasion.” • “I am sorry to inform you that we will not be able to publish your manuscript.” Deflective rejection • “We have considered your manuscript, but our decision is that it would be better placed elsewhere.” • “This is not something that we typically publish, and so we are not able to use it as such.” • “I enjoyed reading it, but this really isn’t for us.” Statistical rejection • “We receive over 8,000 submissions each year and accept fewer than 10% of them.” • “We receive a very large number of submissions each year and therefore have to be highly selective.” • “Our queue for such pieces now extends out to more than a year.” pains of the submission process melted away and we applauded the reviewers for their cogent insights and deep wisdom. The careful reader may note that our publication success was inversely proportional to the similarity of the original work (now termed the “Sykes-Nichols phenomenon”). What had become of that first draft? With dogged perseverance, we had ruthlessly purged and abandoned whole sec- tions of our precious text. Had the MREPR truly translated into pub- lication success? Or had we merely reinforced a timeless academic reality: In this publish-or-perish world, papers sometimes need to perish in order to be published. ● REFERENCE Sykes DB, Nichols DN. There is no denying it, our medical language needs an update. J Grad Med Educ. 2015;7:137-8. David B. Sykes, MD, PhD, is assistant professor of medicine at Harvard Medical School; Michael T. Sykes, PhD, is a bioinformatics scientist in San Diego and the younger brother of David Sykes; Darren N. Nichols, MD, is associate professor of family medicine at the University of Alberta in Edmonton, Canada. ASH Clinical News 13