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VOLUME 05 | NUMBER 02 JANUARY 2019 ANNUAL MEETING EDITION Around the Network AMERICAN SOCIETY OF HEMATOLOGY (ASH) HEADQUARTERS 2021 L Street NW, Suite 900 Washington, DC 20036 www.hematology.org Tel: [phone] IN THIS ISSUE on location A Record-Brekaing Year for Drug Approvals EDITOR-IN-CHIEF Mikkael Sekeres, MD, MS Vice-Chair for Clinical Research Director, Leukemia Program Cleveland Clinic, Taussig Cancer Institute Cleveland, OH Experts offer clinical and regulatory perspectives on three new agents for nonmalignant hematologic disorders: emapalumab, eltrombopag, and emicizumab. 16 ASSOCIATE EDITORS clinical news Elizabeth Brém, MD UC Irvine Medical Center Orange, CA Beth Faiman, CNP, PhD Cleveland Clinic Cleveland, OH Alice Ma, MD University of North Carolina School of Medicine Chapel Hill, NC David Steensma, MD Dana-Farber Cancer Institute Boston, MA New Approaches, Better Outcomes This month, we take a deep dive into the 2018 ASH Annual Meeting, including more data supporting ibrutinib for older patients with chronic lymphocytic leukemia and big data initiatives to improve prognosis in myelodysplastic syndromes. 10  Can Selinexor STOMP Out Relapsed/ Refractory Myeloma? 12 R  avulizumab: A New Option for Paroxysmal Nocturnal Hemoglobinuria 13  Similar Outcomes With Different Treatment Schedules in Older Patients With AML 16 Keith Stewart, MBChB, MBA Mayo Clinic Scottsdale, AZ PUBLISHER American Medical Communications (AMC) EDITORIAL MANAGING EDITORS Kristin Hubing, ASH Ariel Jones-DeMaio, AMC EDITORIAL ASSOCIATE Laurie Adamson, ASH ART DIRECTOR Ari Mihos ASSISTANT ART DIRECTORS Charlene DePrizio John Salesi DIGITAL PROJECTS MANAGER Chris Gedikli ADVERTISING ASHCLINICALNEWS.ORG @ASHCLINICALNEWS The 60th ASH Annual Meeting & Exposition featured a jam-packed scientific and education program. This special issue includes more reports from the meeting, but you can visit ashclinicalnews.org/on- location for our complete coverage, including exclusive content available only online. You can also watch our exclusive interviews with presenters and experts we spoke with at the meeting by visiting ashclinicalnews.org/ multimedia. Search #ASH18 to catch up on what you missed at the annual meeting and make sure to follow us at @ASHClinicalNews. And don’t forget to sign up to receive our eNewsletters to have the latest updates from ASH Clinical News delivered to your inbox: ashclinicalnews.org/ enewsletter-sign-up. ACCOUNT DIRECTORS Nick Luciano [email protected] Gene Conselyea [email protected] Phil Soufleris [email protected] Recruitment advertising orders can be sent to: CLASSIFIEDS ACCOUNT MANAGER Lauren Morgan Visit us at ashclinicalnews.org Follow us on Twitter @ASHClinicalNews ©2019 by the American Society of Hematology. All materials contained in this newsletter are protected by copyright laws and may not be used, reproduced, or oth- erwise exploited in any manner without the express prior written permission of ASH Clinical News. Any third-party materials communicated to ASH Clinical News become its copyrighted property and may be used, reproduced, or otherwise exploited by ASH Clinical News. ASHClinicalNews.org Subscription inquiries should be sent to: [email protected] All correspondence for the American Society of Hematology should be sent to: American Society of Hematology, 2021 L Street NW, Suite 900, Washington DC 20036. Neither the American Society of Hematology nor the publisher is responsible for statements made by any editor or contributor. Statements, editorials, or opinions expressed in ASH Clinical News magazine do not necessarily represent official policy of the American Society of Hematology unless so stated. No responsibility is assumed by the American Society of Hematology or the Publisher for any injury or damage to persons or property as a matter of product liability, negligence or otherwise or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Although all advertising material published in ASH Clinical News magazine is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement by the American Society of Hematology or the Publisher of the quality or value of such product or of the claim made of it by its manufacturer. About the American Society of Hematology The American Society of Hematology (ASH) is the world’s largest professional society concerned with the causes and treatments of blood disorders. The mission of the Society is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and the immunologic, hemostatic and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology. ASH Clinical News (ISSN 2375-8120) is published monthly by American Medical Communications, 630 Madison Avenue, 2nd Floor, Manalapan, NJ 07726. Periodicals postage paid at Freehold, NJ and additional mailing offices. POSTMASTER: Send address changes to American Medical Communications, 630 Madison Avenue, 2nd Floor, Manalapan, NJ 07726. ©Copyright, 2019. ASH Clinical News 5