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and one patient died from septic shock. After
a median follow-up of 38.8 months (range
= 29.9-53.8 months), the rate of one-year
survival was 88.5 percent (n=23; p<0.0001)
among the 26 patients undergoing transplant.
In the intention-to-transplant analysis (which
comprised all study participant), the study
also met its primary endpoint with a one-year
OS rate of 84.7 percent (p<0.0001).
The researchers also reported a one-year
treatment-related mortality rate of 11.5 percent;
TABLE 3.
Patients’ Pre-Transplant Characteristics
N (%) or Median (Range)
≥2 Courses previous immunosuppressive treatment
Time from SAA diagnosis to transplantation
11 (42.3%)
11.9 months (8.7-17.8)
>20 RBC units infused 18 (69%)
>20 platelet units transfusions 22 (85%)
SAA = severe aplastic anemia; RBC = red blood cells