ASH Clinical News ACN_4.5_FULL_ISSUE_DIGITAL - Page 6

Editor ’ s Corner

Updates to Our Style Guide for the Sartorially Challenged

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The content of the Editor ’ s Corner is the opinion of the author and does not represent the official position of the American Society of Hematology unless so stated .
Have a comment about this editorial ? Let us know what you think ; we welcome your feedback . Email the editor at ACNEditor @ hematology . org .
VERY SO OFTEN , the crackerjack editorial team of ASH Clinical News gets together and discusses style .
No , not of the sartorial variety , particularly as mine tends toward chinos , a shirt with a non-asphyxiating collar , and comfortable shoes – matching colors and patterns be damned . This is a combination I like to call “ hematologist fashion-backwards ,” or a “ smear ” of style .
I refer instead to style of the writing variety . We have evolved over the past few years in an effort to improve our readability , particularly with respect to clarity of text , and to respond to trends we see in medical journals and other magazines , along with the lay press . We also strive for neutrality in reporting and try not to be taken in by the subtle vaunting of scientific findings that creep ever-so-insidiously into even the most prestigious journals .
Here are some examples . As always , we welcome your input into how we can better present you with hematology news – and , indeed , some of these changes have resulted from your suggestions ! Feel free to email us at ACNEditor @ hematology . org .
Conflicts of Interest We now provide information regarding authors ’ conflicts of interest at the end of each article about a scientific publication and note whether “ editorial assistance ” was provided by the study sponsor in writing the manuscript . This gives readers additional information to place research findings in the context of what may or may not be subtle influences on the study ’ s results or interpretations . The details about conflicts may not be comprehensive , though , as we rely on what a journal reports as a conflict , which itself may rely on what authors report as their conflicts . Authors may not always be forthcoming with complete information . I have occasionally reviewed manuscripts for journals , for example , that are written largely by pharmaceutical company employees and that support use of that company ’ s drug , yet the authors did not disclose their employment by the company as a conflict . Caveat emptor , as my son the Latin scholar might say , and don ’ t be afraid to check out the Physician Payments Sunshine Act website yourself if you have doubts .
A New Standard of Care Speaking of conflicts of interest , the most common one that , ironically , never requires a disclosure is the relationship between a manuscript reporting positive study results and the betterment of one ’ s career . Success , particularly in academics , is often predicated on self-promotion . In science , though , the data should speak for itself . ( Nota bene : grammatical error is deliberate , as data should take a plural .) Frequently , we see phrases in journal articles that claim a given finding is “ practice-changing ” or represents “ a new standard of care .”
However , a change in practice or new standard is defined functionally – one actually has to observe patterns of adoption of a paradigm over a period of time , and not when research is first published , to make such claims . We will continue to present just the facts of research , try to place them in context , and leave the editorials to … well … our editors .
Email News Content Here ’ s a fun fact you may not realize about magazines , journals , and newspapers : The size of an issue depends on the number of advertisements sold . It isn ’ t as if we decide , “ It ’ s December , I ’ m in the mood for an issue with 140 pages ! But let ’ s keep it small in February because ,
Mikkael A . Sekeres , MD , MS , is director of the Leukemia Program at the Cleveland Clinic in Cleveland , OH . after all , who likes February ?” Advertising content is restricted to no more than 75 percent of more than half the issues published during any 12-month period to qualify for periodical mailing status . Advertising revenue also offsets the costs of printing , and our issue sizes increase or decrease to sustain at least a 50:50 ratio of editorial to maintain our standards .
We augment this with our online content . While we believe our website is a great venue for stories originating from places like regulatory agencies , the Hill , or cross-discipline articles , we recognized that we could not turn the same critical eye to reports of scientific findings as we do to reports on journal articles in our print edition . Consequently , we have largely eliminated coverage of study results from the “ Online Exclusives ” emails you receive from us .
Simple Statistics There is an old joke among epidemiologists : One epidemiologist encounters another at an epidemiology meeting . The first says to the second : “ Oh , it ’ s so nice to see you ! How ’ s your family doing ?” The second replies : “ Well , compared with what ?”
I know , you ’ re probably laughing on the inside , right ? Statements such as “ greater response ,” “ fewer toxicities ,” and “ higher rates ” riddle scientific abstracts and manuscripts , but without supporting statistics or comparison groups , they are no more than hollow words . Recognizing the sophistication of our readership ( many of whom are used to reading primary scientific articles ), we provide measures of comparisons when available , and have put such phrases in context when formal analyses are lacking .
How I Treat In Brief Guilty pleasure confessions : I am a total fan of the Game of Thrones books and HBO series ( and if I had to choose one person alive or dead , real or fictional , with whom to have dinner , it would be Tyrion “ The Imp ” Lannister , a flagon of Dornish wine included with the meal ). I also love the “ How I Treat ” series in Blood . It ’ s great content , with just the right mix of data-driven guidance and practical recommendations when data are lacking . Bob Löwenberg , MD , PhD , and Nancy Berliner , MD , the editor-in-chief and deputy editor , respectively , of Blood , graciously supported our extracting some of these choice pieces in a précis every other month in ASH Clinical News . These are capsule summaries , and online we provide links to the full treatment in Blood , which we encourage you to visit .
I suspect that Tyrion , as hand to Queen Daenerys Targaryen , mother of dragons , rightful heir to the Iron Throne , is also a frequent purveyor of Blood , and of ASH Clinical News . They ’ re the most widely read publications in all of Westeros , with 83 percent of the literate population reporting perusing them , compared with 21 percent who read scrolls or “ scraps of parchment delivered by ravens ” ( p < 0.01 ).
Mikkael Sekeres , MD , MS Editor-in-Chief
4 ASH Clinical News April 2018
Editor’s Corner Updates to Our Style Guide for the Sartorially Challenged E VERY SO OFTEN, the crackerjack editorial team of ASH Clinical News gets together and discusses style. No, not of the sartorial variety, particularly as mine tends toward chinos, a shirt with a non-asphyxiating collar, and comfortable shoes – matching colors and patterns be damned. This is a combination I like to call “hematologist fashion-backwards,” or a “smear” of style. I refer instead to style of the writing variety. We have evolved over the past few years in an effort to improve our readability, particularly with respect to clarity of text, and to respond to trends we see in medical journals and other magazines, along with the lay press. We also strive for neutrality in reporting and try not to be taken in by the subtle vaunting of scientific findings that creep ever-so-insidiously into even the most prestigious journals. Here are some examples. As always, we welcome your input into how we can better present you with hematology news – and, indeed, some of these changes have resulted from your suggestions! Feel free to email us at ACNEditor@hematology.org. Conflicts of Interest We now provide information regarding authors’ conflicts of inter- est at the end of each article about a scientific publication and note whether “editorial assistance” was provided by the study sponsor in writing the manuscript. This gives readers additional information to place research findings in the context of what may or may not be subtle influences on the study’s results or interpretations. The details about conflicts may not be comprehensive, though, as we rely on what a journal reports as a conflict, which itself may rely on what authors report as their conflicts. Authors may not always be forthcoming with complete information. I have occasionally reviewed manuscripts for journals, for example, that are written largely by pharmaceutical company employees and that support use of that company’s drug, yet the authors did not disclose their employment by the company as a conflict. Caveat emptor, as my son the Latin scholar might say, and don’t be afraid to check out the Physician Payments Sunshine Act website yourself if you have doubts. after all, who likes February?” Advertising content is restricted to no more than 75 percent of more than half the issues published dur- ing any 12-month period to qualify for periodical mailing status. Advertising revenue also offsets the costs of printing, and our issue sizes increase or decrease to sustain at least a 50:50 ratio of editorial to Mikkael A. Sekeres, MD, MS, maintain our standards. is director of the Leukemia We augment this with our on- Program at the Cleveland Clinic line content. While we believe our in Cleveland, OH. website is a great venue for stories originating from places like regula- tory agencies, the Hill, or cross-discipline articles, we recognized that we could not turn the same critical eye to reports of scientific findings as we do to reports on journal articles in our print edition. Conse- quently, we have largely eliminated coverage of study results from the “Online Exclusives” emails you receive from us. Simple Statistics There is an old joke among epidemiologists: One epidemiologist encounters another at an epidemiology meeting. The first says to the second: “Oh, it’s so nice to see you! How’s your family do- ing?” The second replies: “Well, compared with what?” I know, you’re probably laughing on the inside, right? State- ments such as “greater response,” “fewer toxicities,” and “higher rates” riddle scientific Ʌ͍́ɥ̰Ёݥѡ)ѥхѥѥ́ȁɥͽɽ̰ѡ䁅ɔɔѡ)܁ݽɑ̸I饹ѡͽѥѥȁɕ͡(䁽ݡɔ͕Ѽɕɥ͍ѥѥ̤)ݔɽ٥ɕ́ɥͽ́ݡمٔ)ՍɅ͕́ѕЁݡɵ͕́ɔ)!܁$QɕЁ% ɥ)9܁Mхɐ ɔ)QѕЁѡѽˊé ɹȁ)ѡѡѡȁ)Ёɕɕ͕Ёѡͥѥ)ѡɥM䁽!ѽ)չ́ͼхѕ)!ٔЁЁѡ́ѽɥ)1Ё́܁ݡЁԁѡݔ)ݕȁѡ)ѽȁЁ 9ѽѽ乽ɜ()M 9)ḾѕɕаѡЁѡа)ɽ䰁ٕȁɕեɕ͍́ɔ́ѡɕѥ͡ݕ)͍ɥЁɕѥͥѥٔՑɕձ́ѡѕɵЁ)éɕȸMՍ̰ѥձɱ䁥̰́ѕɕѕ)͕ɽѥ%͍ѡ՝ѡф͡ձȁ͕(9ф聝Ʌѥɽȁ́Ʌє́ф͡ձхԴ)ɅɕՕѱ䰁ݔ͕Ʌ͕́ɹѥ́ѡЁٕ)̃qɅѥtȁɕɕ͕̃q܁хɐɔt)!ݕٕȰɅѥȁ܁хɐ́)չѥ䃊LՅ䁡́Ѽ͕ٔѕɹ́ѥ)ɅٕȁɥѥЁݡɕ͕ɍ́)Չ͡ѼՍ̸]ݥѥՔѼɕ͕ЁЁѡ)́ɕ͕ɍѼѡѕаٔѡѽɥ)Ѽݕȁѽ̸)9́ ѕ)!ɗéոЁԁ䁹Ёɕ锁Ё饹̰ɹ̰)Qͥ锁Ք́ѡյȁٕѥ͔)́ͽ%ЁͻeЁ́ݔq%ӊéȰ'eѡ)ՔݥѠ̄ ЁӊéЁ͵Յ䁉͔)եɔͥ$ѽхѡQɽ)́! <͕ɥ̀$Ѽ͔ͽٔ)ɕȁѥݥѠݡѼٔȰЁݽձQɥ+qQ%Êt1ѕȰɹ͠ݥՑݥѠѡ)$ͼٔѡq!܁$Qɕӊt͕ɥ́ %ӊéɕЁѕа)ݥѠЁѡɥЁфɥٕեɅѥɕ)ѥ́ݡфɔ 3ݕɜ5A)9 ɱȰ5ѡѽȵ䁕ѽȰɕ)ѥٕ䰁 ɅͱѕȁɅѥͽѡ͔)ٕ́́䁽ѡȁѠM 9̸)Q͔ɔձյɥ̰ݔɽ٥́Ѽѡձ)ɕѵЁ ݡݔɅԁѼ٥ͥи)$ЁѡЁQɥ́ѼEՕ́Qɝ啸)ѡȁɅ̰ɥљհȁѼѡ%ɽQɽ́ͼɕՕ)ٕȁ M 9̸QeɔѡЁݥ)ɕՉѥ́]ѕɽ̰ݥѠ́ɍЁѡѕɅє)ձѥɕѥͥѡɕݥѠāɍЁݡ)ɕ͍ɽ́ȃq͍Ʌ́ɍЁٕɕɅٕϊtĤ)5Mɕ̰55L)ѽȵ )ɥ