Erythroid Maturation
Needs to Stay on Track
Chronic anemia may result from an erythroid maturation defect 1,2
Ineffective erythropoiesis may be characterized by a defect in erythroid maturation, which could lead to
chronic anemia and burdensome complications for patients with some hematological diseases. 1-3
Research, however, is expanding what we know.
References: 1. Liang R, Ghaffari S. Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease. Br J Haematol.
2016;174(5):661-673. 2. Santini V. Anemia as the main manifestation of myelodysplastic syndromes. Semin Hematol. 2015;52(4):348-356. 3. Gupta R,
Musallam K, Taher A, Rivella S. Ineffective erythropoiesis: anemia and iron overload. Hematol Oncol Clin N Am. 2018;32(2):213–221.