ASH Clinical News ACN_3.13_FULL_ISSUE_DIGITAL | Page 92

Illuminating an
underlying cause of
hemolytic anemia
Know
PK Deficiency
• Pyruvate kinase (PK) is an enzyme critical for maintaining red blood cell energy levels.
• PK deficiency is the most common cause of hereditary nonspherocytic hemolytic
anemia, yet may be underrecognized. 1-3
When to Suspect PK Deficiency
PK deficiency should be considered in patients with hemolysis and
no findings suggestive of an acquired autoimmune process, red cell
membrane defect, or hemoglobinopathy. 1
Patient identification and diagnosis are taking on new importance.
Learn More at www.knowPKdeficiency.com
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1. Grace RF, Zanella A, Neufeld EJ, Morton DH, Eber S, Yaish H, Glader B.
Erythrocyte Pyruvate Kinase Deficiency: 2015 Status Report. Am J Hematol. 2015
Sep;90(9):825-30.
2. Zanella A, Fermo E, Bianchi P, Chiarelli LR, Valentini G. Pyruvate kinase deficiency:
the genotype-phenotype association. Blood Reviews 2007: 21; 217–231.
3. Zanella A, Bianchi P. RBC pyruvate kinase deficiency: from genetics to clinical
manifestations. Bailliere’s Clin Haematol 2000;13:57-81.
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