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digestnews rheumatoid arthritis
Autumn 2013
Remission in rheumatoid arthritis
harder for the overweight
The research
Overweight and obese people are less likely
to achieve successful remission in early
rheumatoid arthritis compared with those of
normal weight, says a study presented at the
Annual Congress of the European League
Against Rheumatism.
Scientists looked at 346 people who had
been diagnosed with rheumatoid arthritis for
less than 12 months.
Those who were obese or overweight
needed 2.4 times more anti-TNF therapy
throughout the study than people of a normal
weight, and still didn’t achieve similar
remission outcomes.
The implications
“Obesity and rheumatoid arthritis are both
on the rise, with devastating effects on
individuals and society as a whole,” says
researcher Elisa Gremese.
“These data reinforce the link between
obesity and inflammation, and establish that
body mass index is one of the few modifiable
variables influencing the major outcomes in
rheumatoid arthritis.”
Next steps...
“There is an urgent need to address the issues
of overweight and obesity to improve
patients’ chance of successful remission.”
Poor oral hygiene may increase risk of rheumatoid arthritis
found in the blood of people with rheumatoid
arthritis – or those who are at risk of being
affected in the future.
“Periodontitis may impact on rheumatoid
arthritis initiation and progression,” says
Dr David Lappin in the Journal of Clinical
Periodontology. “Understanding such a
relationship will be crucial to improving
preventative and therapeutic strategies for both
diseases independently and in combination.”
Periodontal disease, a disease that attacks the
gum and bone and around the teeth, may
begin changes in the body that increase
susceptibility to rheumatoid arthritis.
A Scottish research team looked at serum
and plaque samples from 39 people being
treated for periodontitis and 36 healthy
people.
Those with the gum disease had higher
levels of certain antibodies that are often
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