Alabama Genomic Health Initiative Annual Report Annual Report-AGHI FINAL | Page 6

LEADERSHIP INNOVATIVE WHY WE ARE LEADERS IN THE FIELD Oversight Committee The AGHI is one of the nation’s first statewide efforts to harness the power of genomic analysis in helping identify those who are at risk for diseases because of genetic abnormalities and to drive continuing research into genetic contributors to health and disease. APPRECIATIVE UAB is grateful for a longstanding history of support from the Alabama Legislature. The AGHI is honored to be able to benefit the citizens of our state by providing the opportunity to be involved in precision medicine Mitchell B. Cohen, MD Chair of UAB Department of Pediatrics *Upon Dr. Partridge’s retirement in July 2017, Dr. Cohen stepped into this role on the oversight committee. COLLABORATIVE Alabama is fortunate to have two nationally recognized institutions that are leaders in genomic medicine. Combining the expertise of UAB – an internationally renowned research university and academic medical center – with that of HudsonAlpha, a leading U.S. genomic center, enhances our capability to transform how we practice medicine. Edward Partridge, MD Director of UAB Comprehensive Cancer Center Rick Myers, PhD President and Science Director at HudsonAlpha Institute for Biotechnology Additional leaders in the UAB School of Medicine on the Oversight Committee COMPREHENSIVE All AGHI activities, policies, and procedures are carried out under the highest ethical standards to protect participant privacy, autonomy, confidentiality, and equity. The AGHI Oversight Committee ensures that maximum value is provided to participants, the research community, and the state of Alabama. Additionally, AGHI has five working groups made up of experts leading defined areas of responsibility, including bioethics, biobanking and bioinformatics, education, genomics, and participant and provider engagement. Etty Benveniste, PhD Senior Associate Dean for Research Administration and Development RESPONSIVE Bruce R. Korf, MD, PhD Chief Genomics Officer of UAB Medicine Alabama Genomic Health Initiative Annual Report Toni Leeth, MPH Associate Dean for Strategic Planning and Administration Principal Investigators The AGHI regularly seeks diverse voices and perspectives through community engagement efforts including town hall meetings, key informant interviews and facilitated deliberative process groups. Feedback from enrolled participants, community leaders, health care providers and business leaders is used to improve ongoing efforts to maintain the highest ethical approach to recruitment, enrollment, education, and return of results. 4 Robert Kimberly, MD Senior Associate Dean for Clinical and Translational Research Greg Barsh, MD, PhD Faculty Investigator and Chair of HudsonAlpha Institute for Biotechnology Matthew Might, PhD Director of UAB Hugh Kaul Precision Medicine Institute www.aghi.org 5