(201) Special Parent 2017 Edition | Page 29

COURTESY OF CHRIS MARKSBURY AUTISM Institute at Johns Hopkins University, where Dr. Richard Kelly had discovered a link between autism and mitochondrial function. “Mitochondria is the power generator in our cells, breaking down nutrients to create energy. When the mitochondria malfunction, the body’s organs, including the brain, may lack the energy to work and develop properly,” Hasson says, causing potential side effects like developmental delays, social impairment and intellectual disability, all common in autistic children. “Dr. Kelly’s research and clinical work for more than 30 years connected mitochondrial dysfunction with autism,” she says, “and he had found a formula to optimize mitochondrial function through a precise combination of vitamins and other naturallyoccurring compounds.” Hasson called her local compounding pharmacy and put together Jake’s exact dose. “It was expensive, it smelled like fish and tasted awful, but he was only 4 so I forced him to drink it. And within six weeks he was talking, walking and really connected,” she says. By age 8, Jake had had enough. “He wouldn’t drink the liquid anymore and taking it in pill form required 30 to 50 pills a day. I couldn’t force him at that age, so he stopped, and within three weeks he had really regressed,” she says. Hasson was referred to the Developmental Neuropsychiatry Program at Columbia University where she met Dr. Suzanne Goh, a pediatric neurologist and mitochondrial researcher. Together, they tried a year of different “We need to create awareness of mitochondrial dysfunction so that parents and physicians know it’s real and that we can do something about it.” Michelle Hasson therapies before deciding Jake needed to be back on the formula. “My career had been in drug development, so Dr. Goh and I called Dr. Kelly and said we need to find a way to make this formula into an easy, mild-tasting, concentrated dose,” says Hasson. After a year in development, during which Jake used other therapies, they had successfully created the tasteless, high-potency powder that would later be called MitoSpectra. “The human body has around a hundred trillion cells and almost all of them have mitochondria,” Goh, MitoMedical’s chief medical officer, says. “MitoSpectra gets inside the cell with key vitamins and compounds to > SPECIAL PARENT | 2017 EDITION 27